Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury.
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ABSTRACT:
SUBMITTER: Rauhauser AA
PROVIDER: S-EPMC4628948 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
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Hedgehog signaling indirectly affects tubular cell survival after obstructive kidney injury.
Rauhauser Alysha A AA Ren Chongyu C Lu Dongmei D Li Binghua B Zhu Jili J McEnery Kayla K Vadnagara Komal K Zepeda-Orozco Diana D Zhou Xin J XJ Lin Fangming F Jetten Anton M AM Attanasio Massimo M
American journal of physiology. Renal physiology 20150819 9
Hedgehog (Hh) is an evolutionary conserved signaling pathway that has important functions in kidney morphogenesis and adult organ maintenance. Recent work has shown that Hh signaling is reactivated in the kidney after injury and is an important mediator of progressive fibrosis. Pericytes and fibroblasts have been proposed to be the principal cells that respond to Hh ligands, and pharmacological attenuation of Hh signaling has been considered as a possible treatment for fibrosis, but the effect o ...[more]
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