Unknown

Dataset Information

0

Molecular Dynamics Simulations of the Temperature Induced Unfolding of Crambin Follow the Arrhenius Equation.


ABSTRACT: Molecular dynamics simulations have been used extensively to model the folding and unfolding of proteins. The rates of folding and unfolding should follow the Arrhenius equation over a limited range of temperatures. This study shows that molecular dynamic simulations of the unfolding of crambin between 500K and 560K do follow the Arrhenius equation. They also show that while there is a large amount of variation between the simulations the average values for the rate show a very high degree of correlation.

SUBMITTER: Dalby A 

PROVIDER: S-EPMC4629273 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

altmetric image

Publications

Molecular Dynamics Simulations of the Temperature Induced Unfolding of Crambin Follow the Arrhenius Equation.

Dalby Andrew A   Shamsir Mohd Shahir MS  

F1000Research 20150820


Molecular dynamics simulations have been used extensively to model the folding and unfolding of proteins. The rates of folding and unfolding should follow the Arrhenius equation over a limited range of temperatures. This study shows that molecular dynamic simulations of the unfolding of crambin between 500K and 560K do follow the Arrhenius equation. They also show that while there is a large amount of variation between the simulations the average values for the rate show a very high degree of co  ...[more]

Similar Datasets

| S-EPMC2737499 | biostudies-literature
| S-EPMC1301720 | biostudies-other
| S-EPMC2923262 | biostudies-literature
| S-EPMC1877756 | biostudies-literature
| S-EPMC8377445 | biostudies-literature
| S-EPMC2480669 | biostudies-literature
| S-EPMC3049775 | biostudies-literature
| S-EPMC5609516 | biostudies-literature
| S-EPMC3388193 | biostudies-literature
| S-EPMC7610910 | biostudies-literature