Ontology highlight
ABSTRACT:
SUBMITTER: Gierut JJ
PROVIDER: S-EPMC4629819 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Gierut Jessica J JJ Lyons Jesse J Shah Manasvi S MS Genetti Casie C Breault David T DT Haigis Kevin M KM
Stem cell research 20150610 1
K-Ras is a monomeric GTPase that controls cellular and tissue homeostasis. Prior studies demonstrated that mutationally activated K-Ras (K-Ras(G12D)) signals through MEK to promote expansion and hyperproliferation of the highly mitotically active transit-amplifying cells (TACs) in the intestinal crypt. Its effect on normally quiescent stem cells was unknown, however. Here, we have used an H2B-Egfp transgenic system to demonstrate that K-Ras(G12D) accelerates the proliferative kinetics of quiesce ...[more]