No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Ontology highlight
ABSTRACT:
SUBMITTER: Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2
PROVIDER: S-EPMC4630206 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Publications
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Hollestelle Antoinette A van der Baan Frederieke H FH Berchuck Andrew A Johnatty Sharon E SE Aben Katja K KK Agnarsson Bjarni A BA Aittomäki Kristiina K Alducci Elisa E Andrulis Irene L IL Anton-Culver Hoda H Antonenkova Natalia N NN Antoniou Antonis C AC Apicella Carmel C Arndt Volker V Arnold Norbert N Arun Banu K BK Arver Brita B Ashworth Alan A Baglietto Laura L Balleine Rosemary R Bandera Elisa V EV Barrowdale Daniel D Bean Yukie T YT Beckmann Lars L Beckmann Matthias W MW Benitez Javier J Berger Andreas A Berger Raanan R Beuselinck Benoit B Bisogna Maria M Bjorge Line L Blomqvist Carl C Bogdanova Natalia V NV Bojesen Anders A Bojesen Stig E SE Bolla Manjeet K MK Bonanni Bernardo B Brand Judith S JS Brauch Hiltrud H Brenner Hermann H Brinton Louise L Brooks-Wilson Angela A Bruinsma Fiona F Brunet Joan J Brüning Thomas T Budzilowska Agnieszka A Bunker Clareann H CH Burwinkel Barbara B Butzow Ralf R Buys Saundra S SS Caligo Maria A MA Campbell Ian I Carter Jonathan J Chang-Claude Jenny J Chanock Stephen J SJ Claes Kathleen B M KBM Collée J Margriet JM Cook Linda S LS Couch Fergus J FJ Cox Angela A Cramer Daniel D Cross Simon S SS Cunningham Julie M JM Cybulski Cezary C Czene Kamila K Damiola Francesca F Dansonka-Mieszkowska Agnieszka A Darabi Hatef H de la Hoya Miguel M deFazio Anna A Dennis Joseph J Devilee Peter P Dicks Ed M EM Diez Orland O Doherty Jennifer A JA Domchek Susan M SM Dorfling Cecilia M CM Dörk Thilo T Silva Isabel Dos Santos IDS du Bois Andreas A Dumont Martine M Dunning Alison M AM Duran Mercedes M Easton Douglas F DF Eccles Diana D Edwards Robert P RP Ehrencrona Hans H Ejlertsen Bent B Ekici Arif B AB Ellis Steve D SD Engel Christoph C Eriksson Mikael M Fasching Peter A PA Feliubadalo Lidia L Figueroa Jonine J Flesch-Janys Dieter D Fletcher Olivia O Fontaine Annette A Fortuzzi Stefano S Fostira Florentia F Fridley Brooke L BL Friebel Tara T Friedman Eitan E Friel Grace G Frost Debra D Garber Judy J García-Closas Montserrat M Gayther Simon A SA Gentry-Maharaj Aleksandra A Gerdes Anne-Marie AM Giles Graham G GG Glasspool Rosalind R Glendon Gord G Godwin Andrew K AK Goodman Marc T MT Gore Martin M Greene Mark H MH Grip Mervi M Gronwald Jacek J Gschwantler Kaulich Daphne D Guénel Pascal P Guzman Starr R SR Haeberle Lothar L Haiman Christopher A CA Hall Per P Halverson Sandra L SL Hamann Ute U Hansen Thomas V O TVO Harter Philipp P Hartikainen Jaana M JM Healey Sue S Hein Alexander A Heitz Florian F Henderson Brian E BE Herzog Josef J T Hildebrandt Michelle A MA Høgdall Claus K CK Høgdall Estrid E Hogervorst Frans B L FBL Hopper John L JL Humphreys Keith K Huzarski Tomasz T Imyanitov Evgeny N EN Isaacs Claudine C Jakubowska Anna A Janavicius Ramunas R Jaworska Katarzyna K Jensen Allan A Jensen Uffe Birk UB Johnson Nichola N Jukkola-Vuorinen Arja A Kabisch Maria M Karlan Beth Y BY Kataja Vesa V Kauff Noah N Kelemen Linda E LE Kerin Michael J MJ Kiemeney Lambertus A LA Kjaer Susanne K SK Knight Julia A JA Knol-Bout Jacoba P JP Konstantopoulou Irene I Kosma Veli-Matti VM Krakstad Camilla C Kristensen Vessela V Kuchenbaecker Karoline B KB Kupryjanczyk Jolanta J Laitman Yael Y Lambrechts Diether D Lambrechts Sandrina S Larson Melissa C MC Lasa Adriana A Laurent-Puig Pierre P Lazaro Conxi C Le Nhu D ND Le Marchand Loic L Leminen Arto A Lester Jenny J Levine Douglas A DA Li Jingmei J Liang Dong D Lindblom Annika A Lindor Noralane N Lissowska Jolanta J Long Jirong J Lu Karen H KH Lubinski Jan J Lundvall Lene L Lurie Galina G Mai Phuong L PL Mannermaa Arto A Margolin Sara S Mariette Frederique F Marme Frederik F Martens John W M JWM Massuger Leon F A G LFAG Maugard Christine C Mazoyer Sylvie S McGuffog Lesley L McGuire Valerie V McLean Catriona C McNeish Iain I Meindl Alfons A Menegaux Florence F Menéndez Primitiva P Menkiszak Janusz J Menon Usha U Mensenkamp Arjen R AR Miller Nicola N Milne Roger L RL Modugno Francesmary F Montagna Marco M Moysich Kirsten B KB Müller Heiko H Mulligan Anna Marie AM Muranen Taru A TA Narod Steven A SA Nathanson Katherine L KL Ness Roberta B RB Neuhausen Susan L SL Nevanlinna Heli H Neven Patrick P Nielsen Finn C FC Nielsen Sune F SF Nordestgaard Børge G BG Nussbaum Robert L RL Odunsi Kunle K Offit Kenneth K Olah Edith E Olopade Olufunmilayo I OI Olson Janet E JE Olson Sara H SH Oosterwijk Jan C JC Orlow Irene I Orr Nick N Orsulic Sandra S Osorio Ana A Ottini Laura L Paul James J Pearce Celeste L CL Pedersen Inge Sokilde IS Peissel Bernard B Pejovic Tanja T Pelttari Liisa M LM Perkins Jo J Permuth-Wey Jenny J Peterlongo Paolo P Peto Julian J Phelan Catherine M CM Phillips Kelly-Anne KA Piedmonte Marion M Pike Malcolm C MC Platte Radka R Plisiecka-Halasa Joanna J Poole Elizabeth M EM Poppe Bruce B Pylkäs Katri K Radice Paolo P Ramus Susan J SJ Rebbeck Timothy R TR Reed Malcolm W R MWR Rennert Gad G Risch Harvey A HA Robson Mark M Rodriguez Gustavo C GC Romero Atocha A Rossing Mary Anne MA Rothstein Joseph H JH Rudolph Anja A Runnebaum Ingo I Salani Ritu R Salvesen Helga B HB Sawyer Elinor J EJ Schildkraut Joellen M JM Schmidt Marjanka K MK Schmutzler Rita K RK Schneeweiss Andreas A Schoemaker Minouk J MJ Schrauder Michael G MG Schumacher Fredrick F Schwaab Ira I Scuvera Giulietta G Sellers Thomas A TA Severi Gianluca G Seynaeve Caroline M CM Shah Mitul M Shrubsole Martha M Siddiqui Nadeem N Sieh Weiva W Simard Jacques J Singer Christian F CF Sinilnikova Olga M OM Smeets Dominiek D Sohn Christof C Soller Maria M Song Honglin H Soucy Penny P Southey Melissa C MC Stegmaier Christa C Stoppa-Lyonnet Dominique D Sucheston Lara L Swerdlow Anthony A Tangen Ingvild L IL Tea Muy-Kheng MK Teixeira Manuel R MR Terry Kathryn L KL Terry Mary Beth MB Thomassen Mads M Thompson Pamela J PJ Tihomirova Laima L Tischkowitz Marc M Toland Amanda Ewart AE Tollenaar Rob A E M RAEM Tomlinson Ian I Torres Diana D Truong Thérèse T Tsimiklis Helen H Tung Nadine N Tworoger Shelley S SS Tyrer Jonathan P JP Vachon Celine M CM Van 't Veer Laura J LJ van Altena Anne M AM Van Asperen C J CJ van den Berg David D van den Ouweland Ans M W AMW van Doorn Helena C HC Van Nieuwenhuysen Els E van Rensburg Elizabeth J EJ Vergote Ignace I Verhoef Senno S Vierkant Robert A RA Vijai Joseph J Vitonis Allison F AF von Wachenfeldt Anna A Walsh Christine C Wang Qin Q Wang-Gohrke Shan S Wappenschmidt Barbara B Weischer Maren M Weitzel Jeffrey N JN Weltens Caroline C Wentzensen Nicolas N Whittemore Alice S AS Wilkens Lynne R LR Winqvist Robert R Wu Anna H AH Wu Xifeng X Yang Hannah P HP Zaffaroni Daniela D Pilar Zamora M M Zheng Wei W Ziogas Argyrios A Chenevix-Trench Georgia G Pharoah Paul D P PDP Rookus Matti A MA Hooning Maartje J MJ Goode Ellen L EL
Gynecologic oncology 20150502 2
<h4>Objective</h4>Clinical genetic testing is commercially available for rs61764370, an inherited variant residing in a KRAS 3' UTR microRNA binding site, based on suggested associations with increased ovarian and breast cancer risk as well as with survival time. However, prior studies, emphasizing particular subgroups, were relatively small. Therefore, we comprehensively evaluated ovarian and breast cancer risks as well as clinical outcome associated with rs61764370.<h4>Methods</h4>Centralized ...[more]
