Demonstration of nonlinearity bias in the measurement of the apparent diffusion coefficient in multicenter trials.

ABSTRACT:

Purpose

Characterize system-specific bias across common magnetic resonance imaging (MRI) platforms for quantitative diffusion measurements in multicenter trials.

Methods

Diffusion weighted imaging (DWI) was performed on an ice-water phantom along the superior-inferior (SI) and right-left (RL) orientations spanning ± 150 mm. The same scanning protocol was implemented on 14 MRI systems at seven imaging centers. The bias was estimated as a deviation of measured from known apparent diffusion coefficient (ADC) along individual DWI directions. The relative contributions of gradient nonlinearity, shim errors, imaging gradients, and eddy currents were assessed independently. The observed bias errors were compared with numerical models.

Results

The measured systematic ADC erro

SUBMITTER: Malyarenko DI 

PROVIDER: S-EPMC4630210 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature