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Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia.


ABSTRACT: Hemispheric specialization of the human brain is a marker of successful neurodevelopment. Altered brain asymmetry that has been repeatedly reported in schizophrenia may represent consequences of disrupted neurodevelopment in the disorder. However, a complete picture of functional specialization in the schizophrenic brain and its connectional substrates is yet to be unveiled.To quantify intrinsic hemispheric specialization at cortical and subcortical levels and to reveal potential disease effects in schizophrenia.Resting-state functional connectivity magnetic resonance imaging has been previously used to quantitatively measure hemispheric specialization in healthy individuals in a reliable manner. We quantified the intrinsic hemispheric specialization at the whole brain level in 31 patients with schizophrenia and 37 demographically matched healthy controls from November 28, 2007, through June 29, 2010, using resting-state functional magnetic resonance imaging.The caudate nucleus and cortical regions with connections to the caudate nucleus had markedly abnormal hemispheric specialization in schizophrenia. Compared with healthy controls, patients exhibited weaker specialization in the left, but the opposite pattern in the right, caudate nucleus (P?

SUBMITTER: Mueller S 

PROVIDER: S-EPMC4630217 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature

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Abnormalities in hemispheric specialization of caudate nucleus connectivity in schizophrenia.

Mueller Sophia S   Wang Danhong D   Pan Ruiqi R   Holt Daphne J DJ   Liu Hesheng H  

JAMA psychiatry 20150601 6


<h4>Importance</h4>Hemispheric specialization of the human brain is a marker of successful neurodevelopment. Altered brain asymmetry that has been repeatedly reported in schizophrenia may represent consequences of disrupted neurodevelopment in the disorder. However, a complete picture of functional specialization in the schizophrenic brain and its connectional substrates is yet to be unveiled.<h4>Objectives</h4>To quantify intrinsic hemispheric specialization at cortical and subcortical levels a  ...[more]

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