Dataset Information

Joint effusion of the knee: potentialities and limitations of ultrasonography.

ABSTRACT: This study aimed at comparing the diagnostic accuracy of ultrasonography (US) and magnetic resonance imaging (MRI) for the detection of joint effusion of the knee.For this retrospective study, approbation by the institutional review board was not required, and written informed consent from the patients was waived. One hundred and fifty-eight patients (83 men and 75 women; median age 41.2 years; age range 13-81 years) who underwent US and MRI of the knee were included in the study. The sensitivity and specificity of US with respect to MRI in the evaluation of the effusion of the knee and in each recess were compared.In evaluating joint effusion of the knee, compared with MRI, US correctly identified 78 of 96 patients with joint effusion, showing a sensitivity of 81.3 % and a specificity of 100 %, with a positive predictive value (PPV) of 100 % and a negative predictive value (NPV) of 77.5 % (p value = 0.001). Various results were obtained comparing ultrasound with MRI, regarding the various recesses.US showed high specificity and sensitivity in diagnosing knee joint effusion and could be used in patients who cannot undergo MRI.

SUBMITTER: Draghi F

PROVIDER: S-EPMC4630268 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Joint effusion of the knee: potentialities and limitations of ultrasonography.

Draghi Ferdinando F Urciuoli Luigi L Alessandrino Francesco F Corti Riccardo R Scudeller Luigia L Grassi Roberto R

Journal of ultrasound 20150918 4

<h4>Purpose</h4>This study aimed at comparing the diagnostic accuracy of ultrasonography (US) and magnetic resonance imaging (MRI) for the detection of joint effusion of the knee.<h4>Methods</h4>For this retrospective study, approbation by the institutional review board was not required, and written informed consent from the patients was waived. One hundred and fifty-eight patients (83 men and 75 women; median age 41.2 years; age range 13-81 years) who underwent US and MRI of the knee were inclu ...[more]

PMID: 26550074

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Project description:The promoter region is a key element required for the production of RNA in bacteria. While new high-throughput technology allows massively parallel mapping of promoter elements, we still mainly rely on bioinformatics tools to predict such elements in bacterial genomes. Additionally, despite many different prediction tools having become popular to identify bacterial promoters, no systematic comparison of such tools has been performed. Here, we performed a systematic comparison between several widely used promoter prediction tools (BPROM, bTSSfinder, BacPP, CNNProm, IBBP, Virtual Footprint, iPro70-FMWin, 70ProPred, iPromoter-2L, and MULTiPly) using well-defined sequence data sets and standardized metrics to determine how well those tools performed related to each other. For this, we used data sets of experimentally validated promoters from Escherichia coli and a control data set composed of randomly generated sequences with similar nucleotide distributions. We compared the performance of the tools using metrics such as specificity, sensitivity, accuracy, and Matthews correlation coefficient (MCC). We show that the widely used BPROM presented the worse performance among the compared tools, while four tools (CNNProm, iPro70-FMWin, 70ProPred, and iPromoter-2L) offered high predictive power. Of these tools, iPro70-FMWin exhibited the best results for most of the metrics used. We present here some potentials and limitations of available tools, and we hope that future work can build upon our effort to systematically characterize this useful class of bioinformatics tools.IMPORTANCE The correct mapping of promoter elements is a crucial step in microbial genomics. Also, when combining new DNA elements into synthetic sequences, predicting the potential generation of new promoter sequences is critical. Over the last years, many bioinformatics tools have been created to allow users to predict promoter elements in a sequence or genome of interest. Here, we assess the predictive power of some of the main prediction tools available using well-defined promoter data sets. Using Escherichia coli as a model organism, we demonstrated that while some tools are biased toward AT-rich sequences, others are very efficient in identifying real promoters with low false-negative rates. We hope the potentials and limitations presented here will help the microbiology community to choose promoter prediction tools among many available alternatives.

Project description:BackgroundRapid demographic, epidemiological, technological, cultural/behavioural, and educational transitions, as they become more complex, demand new integrated and complementary professional skills and abilities. Interprofessional Education (IPE) is a promising alternative to deal with these changes, especially in courses in the health area. This systematic review was to explore the potentialities and limitations of IPE, from the perspective of undergraduate students, through a thematic synthesis of qualitative studies.MethodsA thematic synthesis of qualitative studies was conducted. The question elaborated for this review was: "What is the impact of interprofessional education on the teaching and learning of students in the health area inserted in Higher Education Institutions?". The search strategy was performed in the electronic databases PubMed, Latin American and Caribbean Literature in Health Sciences (LILACS), Cochrane Library, and Scientific Electronic Library Online (SciELO). In addition, searches were carried out in grey literature on the ERIC platforms, ProQuest Disserts and Theses, and Academic Google. The assessment of the quality of the studies was carried out using the Critical Appraisal Skills Programme tool. Data were summarized through thematic synthesis. From the databases, 8,793 studies were identified. After standardized filters procedures, critical summaries, and assessment of relevance to the eligibility criteria, 14 articles were included.ResultsThe synthesis of the studies revealed the potential of this teaching approach, arranged in three analytical themes: learning from each other and about them; the value of education and interprofessional practice; patient-centred health care. On the other hand, some limitations were also identified, such as barriers related to EIP; the difficulties related to teaching methodologies.ConclusionOvercoming the identified limitations can enhance the results of the IPE, in view of its impact on the education of students and on the health care of the population.

Dataset Information

Joint effusion of the knee: potentialities and limitations of ultrasonography.

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Joint effusion of the knee: potentialities and limitations of ultrasonography.

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