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7T MRI in natalizumab-associated PML and ongoing MS disease activity: A case study.

ABSTRACT:

Objective

To assess the ability of ultra-high-field MRI to distinguish early progressive multifocal leukoencephalopathy (PML) from multiple sclerosis (MS) lesions in a rare case of simultaneous presentation of natalizumab-associated PML and ongoing MS activity.

Methods

Advanced neuroimaging including 1.5T, 3T, and 7T MRI with a spatial resolution of up to 0.08 mm(3) was performed.

Results

7T MRI differentiated between PML-related and MS-related brain damage in vivo. Ring-enhancing MS plaques displayed a central vein, whereas confluent PML lesions were preceded by punctate or milky way-like T2 lesions.

Conclusions

Given the importance of early diagnosis of treatment-associated PML, future systematic studies are warranted to assess the value of highly resolving MRI in differentiating between early PML- and MS-induced brain parenchymal lesions.

SUBMITTER: Sinnecker T

PROVIDER: S-EPMC4630686 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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7T MRI in natalizumab-associated PML and ongoing MS disease activity: A case study.

Sinnecker Tim T Othman Jalal J Kühl Marc M Mekle Ralf R Selbig Inga I Niendorf Thoralf T Kunkel Annett A Wienecke Peter P Kern Peter P Paul Friedemann F Faiss Juergen J Wuerfel Jens J

Neurology(R) neuroimmunology & neuroinflammation 20151029 6

<h4>Objective</h4>To assess the ability of ultra-high-field MRI to distinguish early progressive multifocal leukoencephalopathy (PML) from multiple sclerosis (MS) lesions in a rare case of simultaneous presentation of natalizumab-associated PML and ongoing MS activity.<h4>Methods</h4>Advanced neuroimaging including 1.5T, 3T, and 7T MRI with a spatial resolution of up to 0.08 mm(3) was performed.<h4>Results</h4>7T MRI differentiated between PML-related and MS-related brain damage in vivo. Ring-en ...[more]

PMID: 26568970

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