Microarray-based genomic surveying of gene polymorphisms in Chlamydia trachomatis.
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ABSTRACT:
SUBMITTER: Brunelle BW
PROVIDER: S-EPMC463075 | biostudies-literature | 2004
REPOSITORIES: biostudies-literature
Publications
Microarray-based genomic surveying of gene polymorphisms in Chlamydia trachomatis.
Brunelle Brian W BW Nicholson Tracy L TL Stephens Richard S RS
Genome biology 20040518 6
By comparing two fully sequenced genomes of Chlamydia trachomatis using competitive hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes. Variable genes within 14 uncharacterized strains of C. trachomatis were identified by array analysis and verified by DNA sequencing. These genes may be crucial for understanding chlamydial virulence and pathogenesis. ...[more]
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