Ontology highlight
ABSTRACT:
SUBMITTER: Aygun B
PROVIDER: S-EPMC4631316 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
British journal of haematology 20150122 2
Serial phlebotomy was performed on sixty children with sickle cell anaemia, stroke and transfusional iron overload randomized to hydroxycarbamide in the Stroke With Transfusions Changing to Hydroxyurea trial. There were 927 phlebotomy procedures with only 33 adverse events, all of which were grade 2. Among 23 children completing 30 months of study treatment, the net iron balance was favourable (-8·7 mg Fe/kg) with significant decrease in ferritin, although liver iron concentration remained uncha ...[more]