Ontology highlight
ABSTRACT:
SUBMITTER: Tang Y
PROVIDER: S-EPMC4632035 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Tang Yinglong Y Wang Huiwen H Wei Bin B Guo Yuting Y Gu Lei L Yang Zhiguang Z Zhang Qing Q Wu Yanyun Y Yuan Qi Q Zhao Gang G Ji Guangju G
Scientific reports 20151104
RNA binding protein is identified as an important mediator of aberrant alternative splicing in muscle atrophy. The altered splicing of calcium channels, such as ryanodine receptors (RyRs), plays an important role in impaired excitation-contraction (E-C) coupling in muscle atrophy; however, the regulatory mechanisms of ryanodine receptor 1 (RyR1) alternative splicing leading to skeletal muscle atrophy remains to be investigated. In this study we demonstrated that CUG binding protein 1 (CUG-BP1) w ...[more]