Ontology highlight
ABSTRACT:
SUBMITTER: Casanova M
PROVIDER: S-EPMC4632311 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Casanova M M Gonzalez I J IJ Sprissler C C Zalila H H Dacher M M Basmaciyan L L Späth G F GF Azas N N Fasel N N
Cell death & disease 20151022
Metacaspases (MCAs) are cysteine peptidases expressed in plants, fungi and protozoa, with a caspase-like histidine-cysteine catalytic dyad, but differing from caspases, for example, in their substrate specificity. The role of MCAs is subject to debate: roles in cell cycle control, in cell death or even in cell survival have been suggested. In this study, using a Leishmania major MCA-deficient strain, we showed that L. major MCA (LmjMCA) not only had a role similar to caspases in cell death but a ...[more]