Dataset Information
Dissecting ancestry genomic background in substance dependence genome-wide association studies.
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ABSTRACT: Aims
To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes.Materials & methods
We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes.Results
We observed high ancestry-related frequency differences in common functional alleles in GWAS relevant genes and their interactive partners. Common functional alleles with high frequency differences demonstrated significant effects on the GWAS outcomes.Conclusion
Population differences in SD GWAS outcomes seem not to be influenced by general variation across the genome, but by ancestry-related local haplotype structures at SD-associated loci.
SUBMITTER: Polimanti R
PROVIDER: S-EPMC4632979 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Dissecting ancestry genomic background in substance dependence genome-wide association studies.
Pharmacogenomics 20150812 13
<h4>Aims</h4>To understand the role of ancestral genomic background in substance dependence (SD) genome-wide association studies (GWAS), we analyzed population diversity at genetic loci associated with SD traits and evaluated its effect on GWAS outcomes.<h4>Materials & methods</h4>We investigated 24 genes with variants associated with SD by GWAS; and 82 loci with putative subordinate roles with respect to SD-associated genes.<h4>Results</h4>We observed high ancestry-related frequency differences ...[more]