Ontology highlight
ABSTRACT:
SUBMITTER: Zan H
PROVIDER: S-EPMC4632985 | biostudies-literature | 2001 May
REPOSITORIES: biostudies-literature
Zan H H Komori A A Li Z Z Cerutti A A Schaffer A A Flajnik M F MF Diaz M M Casali P P
Immunity 20010501 5
Ig somatic mutations would be introduced by a polymerase (pol) while repairing DNA outside main DNA replication. We show that human B cells constitutively express the translesion pol zeta, which effectively extends DNA past mismatched bases (mispair extender), and pol eta, which bypasses DNA lesions in an error-free fashion. Upon B cell receptor (BCR) engagement and coculture with activated CD4+ T cells, these lymphocytes upregulated pol zeta, downregulated pol eta, and mutated the Ig and bcl-6 ...[more]