Dataset Information

Association between Dietary Magnesium Intake and Hyperuricemia.

ABSTRACT:

Objective

To examine the cross-sectional associations between dietary magnesium (Mg) intake and hyperuricemia (HU).

Methods

5168 subjects were included in this study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Hyperuricemia (HU) was defined as uric acid ? 416 ?mol/L for male population and ? 360 ?mol/L for female. A multivariable logistic analysis model was applied to test the associations after adjusting a number of potential confounding factors.

Results

The relative odds of the overall prevalence of HU were decreased by 0.57 times in the fourth quintile of Mg intake (OR 0.57, 95% CI 0.35-0.94) and 0.55 times in the fifth quintile (OR 0.55, 95% CI 0.30-1.01) comparing with the lowest quintile, and P for trend was 0.091. The results of multivariable linear regression also suggested a significant inverse association between serum uric acid and Mg intake (? = -0.028, P = 0.022). For male, the relative odds of HU were decreased by 0.62 times in the third quintile of Mg intake (OR 0.62, 95% CI 0.40-0.97), 0.40 times in the fourth quintile (OR 0.40, 95% CI 0.23-0.72) and 0.35 times in the fifth quintile (OR 0.35, 95% CI 0.17-0.71) comparing with the lowest quintile, and P for trend was 0.006. Multivariable adjusted inverse association was also existed between serum uric acid and Mg intake in male population (? = -0.061, P = 0.002). However, no significant association was observed between dietary Mg intake and HU for female.

Conclusions

The findings of this cross-sectional study indicated that dietary Mg intake is inversely associated with HU, independent of some major confounding factors. In addition, this association remains valid for the male subgroup, but not for the female subgroup.

Level of evidence

LevelIII, cross-sectional study.

SUBMITTER: Wang YL

PROVIDER: S-EPMC4633057 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between Dietary Magnesium Intake and Hyperuricemia.

Wang Yi-Lun YL Zeng Chao C Wei Jie J Yang Tuo T Li Hui H Deng Zhen-Han ZH Yang Ye Y Zhang Yi Y Ding Xiang X Xie Dong-Xing DX Yang Tu-Bao TB Lei Guang-Hua GH

PloS one 20151104 11

<h4>Objective</h4>To examine the cross-sectional associations between dietary magnesium (Mg) intake and hyperuricemia (HU).<h4>Methods</h4>5168 subjects were included in this study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Hyperuricemia (HU) was defined as uric acid ≥ 416 μmol/L for male population and ≥ 360 μmol/L for female. A multivariable logistic analysis model was applied to test the associations after adjusting a number of potential con ...[more]

PMID: 26536119

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Dataset Information

Association between Dietary Magnesium Intake and Hyperuricemia.

Objective

Methods

Results

Conclusions

Level of evidence

Publications

Association between Dietary Magnesium Intake and Hyperuricemia.

Similar Datasets

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