Ontology highlight
ABSTRACT:
SUBMITTER: Cui Y
PROVIDER: S-EPMC4633729 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cui Yuqi Y Narasimhulu Chandrakala A CA Liu Lingjuan L Zhang Qingbin Q Liu Patrick Z PZ Li Xin X Xiao Yuan Y Zhang Jia J Hao Hong H Xie Xiaoyun X He Guanglong G Cui Lianqun L Parthasarathy Sampath S Liu Zhenguo Z
Scientific reports 20151105
Low-density lipoprotein (LDL) is non-atherogenic, while oxidized LDL (ox-LDL) is critical to atherosclerosis. N-acetylcysteine (NAC) has anti-atherosclerotic effect with largely unknown mechanisms. The present study aimed to determine if NAC could attenuate in vivo LDL oxidation and inhibit atherosclerosis. A single dose of human native LDL was injected intravenously into male C57BL/6 mice with and without NAC treatment. Serum human ox-LDL was detected 30 min after injection, reached the peak in ...[more]