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Progressing a human embryonic stem-cell-based regenerative medicine therapy towards the clinic.

ABSTRACT: Since the first publication of the derivation of human embryonic stem cells in 1998, there has been hope and expectation that this technology will lead to a wave of regenerative medicine therapies with the potential to revolutionize our approach to managing certain diseases. Despite significant resources in this direction, the path to the clinic for an embryonic stem-cell-based regenerative medicine therapy has not proven straightforward, though in the past few years progress has been made. Here, with a focus upon retinal disease, we discuss the current status of the development of such therapies. We also highlight some of our own experiences of progressing a retinal pigment epithelium cell replacement therapy towards the clinic.

SUBMITTER: Whiting P

PROVIDER: S-EPMC4634002 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Progressing a human embryonic stem-cell-based regenerative medicine therapy towards the clinic.

Whiting Paul P Kerby Julie J Coffey Peter P da Cruz Lyndon L McKernan Ruth R

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20151001 1680

Since the first publication of the derivation of human embryonic stem cells in 1998, there has been hope and expectation that this technology will lead to a wave of regenerative medicine therapies with the potential to revolutionize our approach to managing certain diseases. Despite significant resources in this direction, the path to the clinic for an embryonic stem-cell-based regenerative medicine therapy has not proven straightforward, though in the past few years progress has been made. Here ...[more]

PMID: 26416684

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