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Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans.

ABSTRACT: To use quantitative magnetic resonance imaging (MRI) to test whether mediobasal hypothalamic (MBH) gliosis is associated with obesity and insulin resistance in humans.Sixty-seven participants underwent a fasting blood draw and MRI. Cases with radiologic evidence of MBH gliosis (N?=?22) were identified as the upper tertile of left MBH T2 relaxation time and were compared to controls (N?=?23) from the lowest tertile. In a separate postmortem study, brain slices (N?=?10) through the MBH were imaged by MRI and stained for glial fibrillary acidic protein (GFAP).In all participants, longer T2 relaxation time in the left MBH was associated with higher BMI (P?=?0.01). Compared with controls, cases had longer T2 relaxation times in the right MBH (P?

SUBMITTER: Schur EA 

PROVIDER: S-EPMC4634110 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature

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<h4>Objective</h4>To use quantitative magnetic resonance imaging (MRI) to test whether mediobasal hypothalamic (MBH) gliosis is associated with obesity and insulin resistance in humans.<h4>Methods</h4>Sixty-seven participants underwent a fasting blood draw and MRI. Cases with radiologic evidence of MBH gliosis (N = 22) were identified as the upper tertile of left MBH T2 relaxation time and were compared to controls (N = 23) from the lowest tertile. In a separate postmortem study, brain slices (N  ...[more]

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