Ontology highlight
ABSTRACT:
SUBMITTER: Bradshaw G
PROVIDER: S-EPMC4634355 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Bradshaw Gabrielle G Sutherland Heidi G HG Camilleri Emily T ET Lea Rodney A RA Haupt Larisa M LM Griffiths Lyn R LR
Meta gene 20151022
The methylenetetrahydrofolate reductase (MTHFR) gene codes for the MTHFR enzyme which plays a key role in the pathway of folate and methionine metabolism. Polymorphisms of genes in this pathway affect its regulation and have been linked to lymphoma. In this study we examined whether we could detect an association between two common non-synonymous MTHFR polymorphisms, 677C > T (rs1801133) and 1298A > C (rs1801131), and susceptibility to non-Hodgkin lymphoma (NHL) in an Australian case-control coh ...[more]