Ontology highlight
ABSTRACT:
SUBMITTER: Doebele RC
PROVIDER: S-EPMC4635026 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Doebele Robert C RC Davis Lara E LE Vaishnavi Aria A Le Anh T AT Estrada-Bernal Adriana A Keysar Stephen S Jimeno Antonio A Varella-Garcia Marileila M Aisner Dara L DL Li Yali Y Stephens Philip J PJ Morosini Deborah D Tuch Brian B BB Fernandes Michele M Nanda Nisha N Low Jennifer A JA
Cancer discovery 20150727 10
<h4>Unlabelled</h4>Oncogenic TRK fusions induce cancer cell proliferation and engage critical cancer-related downstream signaling pathways. These TRK fusions occur rarely, but in a diverse spectrum of tumor histologies. LOXO-101 is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors. Preclinical models of LOXO-101 using TRK-fusion-bearing human-derived cancer cell lines demonstrate inhibition of the fusion oncoprotein and cellular proli ...[more]