Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain.
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ABSTRACT:
SUBMITTER: Hameed LS
PROVIDER: S-EPMC4635398 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain.
Hameed L Shahul LS Berg Daniel A DA Belnoue Laure L Jensen Lasse D LD Cao Yihai Y Simon András A
eLife 20151020
Organisms need to adapt to the ecological constraints in their habitat. How specific processes reflect such adaptations are difficult to model experimentally. We tested whether environmental shifts in oxygen tension lead to events in the adult newt brain that share features with processes occurring during neuronal regeneration under normoxia. By experimental simulation of varying oxygen concentrations, we show that hypoxia followed by re-oxygenation lead to neuronal death and hallmarks of an inj ...[more]
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