Ontology highlight
ABSTRACT:
SUBMITTER: Vadyvaloo V
PROVIDER: S-EPMC4635514 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Vadyvaloo Viveka V Viall Austin K AK Jarrett Clayton O CO Hinz Angela K AK Sturdevant Daniel E DE Joseph Hinnebusch B B
Microbiology (Reading, England) 20150324 6
The Yersinia pestis PhoPQ gene regulatory system is induced during infection of the flea digestive tract and is required to produce adherent biofilm in the foregut, which greatly enhances bacterial transmission during a flea bite. To understand the in vivo context of PhoPQ induction and to determine PhoP-regulated targets in the flea, we undertook whole-genome comparative transcriptional profiling of Y. pestis WT and ΔphoP strains isolated from infected fleas and from temperature-matched in vitr ...[more]