Ontology highlight
ABSTRACT:
SUBMITTER: Salmond RJ
PROVIDER: S-EPMC4635570 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Salmond Robert J RJ Brownlie Rebecca J RJ Meyuhas Oded O Zamoyska Rose R
Journal of immunology (Baltimore, Md. : 1950) 20151009 10
Ag-dependent activation of naive T cells induces dramatic changes in cellular metabolism that are essential for cell growth, division, and differentiation. In recent years, the serine/threonine kinase mechanistic target of rapamycin (mTOR) has emerged as a key integrator of signaling pathways that regulate these metabolic processes. However, the role of specific downstream effectors of mTOR function in T cells is poorly understood. Ribosomal protein S6 (rpS6) is an essential component of the rib ...[more]