Ontology highlight
ABSTRACT:
SUBMITTER: Hargreaves CE
PROVIDER: S-EPMC4636148 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Hargreaves Chantal E CE Iriyama Chisako C Rose-Zerilli Matthew J J MJ Nagelkerke Sietse Q SQ Hussain Khiyam K Ganderton Rosalind R Lee Charlotte C Machado Lee R LR Hollox Edward J EJ Parker Helen H Latham Kate V KV Kuijpers Taco W TW Potter Kathleen N KN Coupland Sarah E SE Davies Andrew A Stackpole Michael M Oates Melanie M Pettitt Andrew R AR Glennie Martin J MJ Cragg Mark S MS Strefford Jonathan C JC
PloS one 20151106 11
Cancer immunotherapy has been revolutionised by the use monoclonal antibodies (mAb) that function through their interaction with Fc gamma receptors (FcγRs). The low-affinity FcγR genes are highly homologous, map to a complex locus at 1p23 and harbour single nucleotide polymorphisms (SNPs) and copy number variation (CNV) that can impact on receptor function and response to therapeutic mAbs. This complexity can hinder accurate characterisation of the locus. We therefore evaluated and optimised a s ...[more]