Ontology highlight
ABSTRACT:
SUBMITTER: Woo T
PROVIDER: S-EPMC4636248 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Woo Tetsukan T Okudela Koji K Mitsui Hideaki H Tajiri Michihiko M Rino Yasushi Y Ohashi Kenichi K Masuda Munetaka M
PloS one 20151106 11
We previously reported that patients with lung adenocarcinomas with KRAS gene mutations and strong proliferating activity had poorer outcomes, even in the early stage of the disease. The aim of the present study was to elucidate the potential molecular basis of these highly malignant lung tumors by focusing on S100 proteins (S100A2, S100A7, and S100A11), which are downstream targets of oncogenic KRAS and promoters of tumor progression. The immunohistochemical expression of S100 proteins was exam ...[more]