Ontology highlight
ABSTRACT:
SUBMITTER: Lopez S
PROVIDER: S-EPMC4636465 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Lopez Salvatore S Cocco Emiliano E Black Jonathan J Bellone Stefania S Bonazzoli Elena E Predolini Federica F Ferrari Francesca F Schwab Carlton L CL English Diana P DP Ratner Elena E Silasi Dan-Arin DA Azodi Masoud M Schwartz Peter E PE Terranova Corrado C Angioli Roberto R Santin Alessandro D AD
Molecular cancer therapeutics 20150902 11
HER2/neu gene amplification and PIK3CA driver mutations are common in uterine serous carcinoma (USC) and may represent ideal therapeutic targets against this aggressive variant of endometrial cancer. We examined the sensitivity to neratinib, taselisib, and the combination of the two compounds in in vitro and in vivo experiments using PIK3CA-mutated and PIK3CA wild-type HER2/neu-amplified USC cell lines. Cell viability and cell-cycle distribution were assessed using flow-cytometry assays. Downstr ...[more]