Dataset Information

Lifestyle Intervention in Gastroesophageal Reflux Disease.

ABSTRACT: Gastroesophageal reflux disease (GERD) affects up to 30% of adults in Western populations and is increasing in prevalence. GERD is associated with lifestyle factors, particularly obesity and tobacco smoking, which also threatens the patient's general health. GERD carries the risk of several adverse outcomes and there is widespread use of potent acid-inhibitors, which are associated with long-term adverse effects. The aim of this systematic review was to assess the role of lifestyle intervention in the treatment of GERD.Literature searches were performed in PubMed (from 1946), EMBASE (from 1980), and the Cochrane Library (no start date) to October 1, 2014. Meta-analyses, systematic reviews, randomized clinical trials (RCTs), and prospective observational studies were included.Weight loss was followed by decreased time with esophageal acid exposure in 2 RCTs (from 5.6% to 3.7% and from 8.0% to 5.5%), and reduced reflux symptoms in prospective observational studies. Tobacco smoking cessation reduced reflux symptoms in normal-weight individuals in a large prospective cohort study (odds ratio, 5.67). In RCTs, late evening meals increased time with supine acid exposure compared with early meals (5.2% point change), and head-of-the-bed elevation decreased time with supine acid exposure compared with a flat position (from 21% to 15%).Weight loss and tobacco smoking cessation should be recommended to GERD patients who are obese and smoke, respectively. Avoiding late evening meals and head-of-the-bed elevation is effective in nocturnal GERD.

SUBMITTER: Ness-Jensen E

PROVIDER: S-EPMC4636482 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Lifestyle Intervention in Gastroesophageal Reflux Disease.

Ness-Jensen Eivind E Hveem Kristian K El-Serag Hashem H Lagergren Jesper J

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20150506 2

<h4>Background & aims</h4>Gastroesophageal reflux disease (GERD) affects up to 30% of adults in Western populations and is increasing in prevalence. GERD is associated with lifestyle factors, particularly obesity and tobacco smoking, which also threatens the patient's general health. GERD carries the risk of several adverse outcomes and there is widespread use of potent acid-inhibitors, which are associated with long-term adverse effects. The aim of this systematic review was to assess the role ...[more]

PMID: 25956834

Similar Datasets

Project description:BACKGROUND: Gastroesophageal reflux disease (GERD) is a very common disorder worldwide, comprised of reflux esophagitis (RE) and non-erosive reflux disease (NERD). As more than half of GERD patients are classified into the NERD group, precise evaluation of bothersome epigastric symptoms is essential. Nevertheless, compared with many reports targeting endoscopic reflux esophagitis, large-scale studies focusing on GERD symptoms have been very scarce. METHODS: To elucidate lifestyle factors affecting GERD symptoms, 19,864 healthy adults in Japan were analyzed. Sub-analyses of 371 proton pump inhibitor (PPI) users and 539 histamine H?-receptor antagonist (H?RA) users were also performed. Using the FSSG (Frequency Scale for the Symptoms of GERD) score as a response variable, 25 lifestyle-related factors were univariately evaluated by Student's t-test or Pearson's correlation coefficient, and were further analyzed with multiple linear regression modelling. RESULTS: Average FSSG scores were 4.8 ± 5.2 for total subjects, 9.0 ± 7.3 for PPI users, and 8.2 ± 6.6 for H?RA users. Among the total population, positively correlated factors and standardized coefficients (?) for FSSG scores are inadequate sleep (? = 0.158), digestive drug users (? = 0.0972 for PPI, ? = 0.0903 for H?RA, and ? = 0.104 for others), increased body weight in adulthood (? = 0.081), dinner just before bedtime (? = 0.061), the habit of midnight snack (? = 0.055), lower body mass index (? = 0.054), NSAID users (? = 0.051), female gender (? = 0.048), lack of breakfast (? = 0.045), lack of physical exercise (? = 0.035), younger age (? = 0.033), antihyperglycemic agents non-users (? = 0.026), the habit of quick eating (? = 0.025), alcohol drinking (? = 0.025), history of gastrectomy (? = 0.024), history of cardiovascular disease (? = 0.020), and smoking (? = 0.018). Positively correlated factors for PPI users are female gender (? = 0.198), inadequate sleep (? = 0.150), lack of breakfast (? = 0.146), antihypertensive agent non-users (? = 0.134), and dinner just before bedtime (? = 0.129), whereas those for H?RA users are inadequate sleep (? = 0.248), habit of midnight snack (? = 0.160), anticoagulants non-users (? = 0.106), and antihypertensive agents non-users (? = 0.095). CONCLUSIONS: Among many lifestyle-related factors correlated with GERD symptoms, poor quality of sleep and irregular dietary habits are strong risk factors for high FSSG scores. At present, usual dose of PPI or H?RA in Japan cannot fully relieve GERD symptoms.

Project description:BackgroundDietary and lifestyle habits related to troublesome gastroesophageal reflux symptoms (tGERS) differ significantly across populations. There have yet to be studies on the Vietnamese population.AimsTo identify dietary and lifestyle habits associated with tGERS in Vietnamese adults.MethodsA cross-sectional survey was conducted among Vietnamese adults aged 18 years and older from March 2023 to May 2023. Participants were recruited online through a widely read national newspaper and Facebook, one of Vietnam's most popular social media platforms. The survey questionnaire comprised 27 questions covering participants' basic demographic information, dietary and lifestyle habits, the presence and characteristics of tGERS, and inquiries about specific dietary and lifestyle patterns, foods, and beverages associated with tGERS.ResultsA total of 4,400 valid responses were collected, including 2050 participants without tGERS and 2,350 participants with tGERS. Multivariate analysis showed several factors associated with tGERS, including eating beyond fullness (OR 1.383, CI95% 1.127-1.698), tight clothing (OR 1.627, CI95% 1.256-2.107), stress (OR 1.566, CI95% 1.363-1.800), and insomnia (OR 1.321, CI95% 1.129-1.546). Among habits associated with tGERS, eating beyond fullness was the most frequently reported (64.6%). Interestingly, although a short meal-to-bed time and staying up late after midnight were not risk factors for tGERS, they were two common factors associated with tGERS in symptomatic participants, particularly those with nocturnal reflux symptoms. For food triggers, the three most common ones were greasy foods (71.9%), sour/spicy soups (64.7%), and citrus fruits (36.0%). In terms of beverages, carbonated soft drinks were at the top of triggering tGERS (40.3%), and beer and orange juice were the second and third most common triggers, accounting for 35.7 and 30.6%, respectively.ConclusionWe reported the dietary and lifestyle habits associated with tGERS in Vietnamese adults for the first time. These findings will serve as a basis for future studies on the primary prevention and nondrug management of tGERS in Vietnam.

Dataset Information

Lifestyle Intervention in Gastroesophageal Reflux Disease.

Publications

Lifestyle Intervention in Gastroesophageal Reflux Disease.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets