Ontology highlight
ABSTRACT:
SUBMITTER: Guinney J
PROVIDER: S-EPMC4636487 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Guinney Justin J Dienstmann Rodrigo R Wang Xin X de Reyniès Aurélien A Schlicker Andreas A Soneson Charlotte C Marisa Laetitia L Roepman Paul P Nyamundanda Gift G Angelino Paolo P Bot Brian M BM Morris Jeffrey S JS Simon Iris M IM Gerster Sarah S Fessler Evelyn E De Sousa E Melo Felipe F Missiaglia Edoardo E Ramay Hena H Barras David D Homicsko Krisztian K Maru Dipen D Manyam Ganiraju C GC Broom Bradley B Boige Valerie V Perez-Villamil Beatriz B Laderas Ted T Salazar Ramon R Gray Joe W JW Hanahan Douglas D Tabernero Josep J Bernards Rene R Friend Stephen H SH Laurent-Puig Pierre P Medema Jan Paul JP Sadanandam Anguraj A Wessels Lodewyk L Delorenzi Mauro M Kopetz Scott S Vermeulen Louis L Tejpar Sabine S
Nature medicine 20151012 11
Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international consortium dedicated to large-scale data sharing and analytics across expert groups. We show marked interconnectivity between six independent classification systems coalescing into four consensus molecular subtypes (CMSs) with distinguishing fea ...[more]