Ontology highlight
ABSTRACT:
SUBMITTER: Lottersberger F
PROVIDER: S-EPMC4636737 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Lottersberger Francisca F Karssemeijer Roos Anna RA Dimitrova Nadya N de Lange Titia T
Cell 20151101 4
Increased mobility of chromatin surrounding double-strand breaks (DSBs) has been noted in yeast and mammalian cells but the underlying mechanism and its contribution to DSB repair remain unclear. Here, we use a telomere-based system to track DNA damage foci with high resolution in living cells. We find that the greater mobility of damaged chromatin requires 53BP1, SUN1/2 in the linker of the nucleoskeleton, and cytoskeleton (LINC) complex and dynamic microtubules. The data further demonstrate th ...[more]