Interferon-γ-mediated allograft rejection exacerbates cardiovascular disease of hyperlipidemic murine transplant recipients.

ABSTRACT:

Rationale

Transplantation, the most effective therapy for end-stage organ failure, is markedly limited by early-onset cardiovascular disease (CVD) and premature death of the host. The mechanistic basis of this increased CVD is not fully explained by known risk factors.

Objective

To investigate the role of alloimmune responses in promoting CVD of organ transplant recipients.

Methods and results

We established an animal model of graft-exacerbated host CVD by combining murine models of atherosclerosis (apolipoprotein E-deficient recipients on standard diet) and of intra-abdominal graft rejection (heterotopic cardiac transplantation without immunosuppression). CVD was absent in normolipidemic hosts receiving allogeneic grafts and varied in severity among hyperlipidemic gr

SUBMITTER: Zhou J 

PROVIDER: S-EPMC4636943 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature