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APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern.

ABSTRACT: INTRODUCTION:This study assessed apolipoprotein E (APOE) ?4 carrier status effects on Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal older adults with significant memory concerns (SMC). METHODS:Cognitively normal, SMC, and early mild cognitive impairment participants from Alzheimer's Disease Neuroimaging Initiative were divided by APOE ?4 carrier status. Diagnostic and APOE effects were evaluated with emphasis on SMC. Additional analyses in SMC evaluated the effect of the interaction between APOE and [(18)F]Florbetapir amyloid positivity on CSF biomarkers. RESULTS:SMC ?4+ showed greater amyloid deposition than SMC ?4-, but no hypometabolism or medial temporal lobe (MTL) atrophy. SMC ?4+ showed lower amyloid beta 1-42 and higher tau/p-tau than ?4-, which was most abnormal in APOE ?4+ and cerebral amyloid positive SMC. DISCUSSION:SMC APOE ?4+ show abnormal changes in amyloid and tau biomarkers, but no hypometabolism or MTL neurodegeneration, reflecting the at-risk nature of the SMC group and the importance of APOE in mediating this risk.

SUBMITTER: Risacher SL

PROVIDER: S-EPMC4637003 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern.

Risacher Shannon L SL Kim Sungeun S Nho Kwangsik K Foroud Tatiana T Shen Li L Petersen Ronald C RC Jack Clifford R CR Beckett Laurel A LA Aisen Paul S PS Koeppe Robert A RA Jagust William J WJ Shaw Leslie M LM Trojanowski John Q JQ Weiner Michael W MW Saykin Andrew J AJ

Alzheimer's & dementia : the journal of the Alzheimer's Association 20150507 12

<h4>Introduction</h4>This study assessed apolipoprotein E (APOE) ε4 carrier status effects on Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal older adults with significant memory concerns (SMC).<h4>Methods</h4>Cognitively normal, SMC, and early mild cognitive impairment participants from Alzheimer's Disease Neuroimaging Initiative were divided by APOE ε4 carrier status. Diagnostic and APOE effects were evaluated with emphasis on SMC. Additional analyses ...[more]

PMID: 25960448

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Project description:IntroductionConcern about falling is a prevalent worry among community-dwelling older adults and may contribute to a decline in physical and mental health. This study aimed to examine the association between mobility performance and concern about falling.MethodsOlder adults aged 65 years and older, with Mini-Mental State Examination score ≥24, and ambulatory (with or without the assistive device) were included. Concern about falling was evaluated with Falls Efficacy Scale-International (FES-I) scores. Participants with high concern about falling were identified using the cutoff of FES-I ≥23. Participants' motor capacity was assessed in standardized walking tests under single- and dual-task conditions. Participants' mobility performance was measured based on a 48-h trunk accelerometry signal from a wearable pendant sensor.ResultsNo significant differences were observed at participant characteristics across groups with different levels of concern about falling (low: N = 64, age = 76.3 ± 7.2 years, female = 46%; high: N = 59, age = 79.3 ± 9.1 years, female = 47%), after propensity matching with BMI, age, depression, and cognition. With adjustment of motor capacity (stride velocity and stride length under single- and dual-task walking conditions), participants with high concern about falling had significantly poorer mobility performance than those with low concern about falling, including lower walking quantity (walking bouts, steps and time per day, and walking bout average, walking bout variability, and longest walking bout, p ≤ 0.013), and poorer daily-life gait (stride velocity and gait variability, p ≤ 0.023), and poorer walking quality (frontal gait symmetry, and trunk acceleration and velocity intensity, p ≤ 0.041). The selected mobility performance metrics (daily steps and frontal gait symmetry) could significantly contribute to identifying older adults with high concern about falling (p ≤ 0.042), having better model performance (p = 0.036) than only walking quantity (daily steps) with adjustment of confounding effects from the motor capacity (stride length under dual-task walking condition).ConclusionThere is an association between mobility performance and concern about falling in older adults. Mobility performance metrics can serve as predictors to identify older adults with high concern about falling, potentially providing digital biomarkers for clinicians to remotely track older adults' change of concern about falling via applications of remote patient monitoring.

Dataset Information

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern.

Publications

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern.

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