Systemic Problems: A perspective on stem cell aging and rejuvenation.
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ABSTRACT:
SUBMITTER: Conboy IM
PROVIDER: S-EPMC4637204 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Systemic Problems: A perspective on stem cell aging and rejuvenation.
Conboy Irina M IM Conboy Michael J MJ Rebo Justin J
Aging 20151001 10
This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in ...[more]
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