Longitudinal assessment of spinal cord injuries in nonhuman primates with quantitative magnetization transfer.

ABSTRACT: This study aimed to evaluate the reproducibility and specificity of quantitative magnetization transfer (qMT) imaging for monitoring spinal cord injuries (SCIs).MRI scans were performed in anesthetized monkeys at 9.4T, before and serially after a unilateral lesion of the cervical spinal cord. A two-pool fitting model was used to derive qMT parameters.qMT measures were reproducible across normal subjects, with an average pool size ratio (PSR) of 0.086?±?0.003 (mean?±?SD) for gray matter, and 0.120?±?0.005 for white matter, respectively. Compared with normal gray matter, the PSR of abnormal tissues rostral and caudal to the injury site decreased by 19.5% (P?

SUBMITTER: Wang F 

PROVIDER: S-EPMC4637273 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature