Ontology highlight
ABSTRACT:
SUBMITTER: Li YD
PROVIDER: S-EPMC4638188 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Medical science monitor : international medical journal of experimental and clinical research 20151103
<h4>Background</h4>Dilated cardiomyopathy (DCM) is characterized by left ventricular enlargement, systolic dysfunction, and heart failure. Both genetic and non-genetic factors have been linked to DCM pathogenesis. Familial DCM (FDCM) accounts for 20%-50% of all DCM cases, highlighting the importance of genetics in pathogenesis. Indeed, more than 40 DCM-associated genes have been identified, including the gene encoding cardiac troponin T type-2 (TNNT2). We examined polymorphisms of the TNNT2 gene ...[more]