Ontology highlight
ABSTRACT:
SUBMITTER: Uzarski JS
PROVIDER: S-EPMC4638211 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Tissue engineering. Part C, Methods 20150624 11
The lack of a functional endothelium on small-diameter vascular grafts leads to intimal hyperplasia and thrombotic occlusion. Shear stress conditioning through controlled hydrodynamics within in vitro perfusion bioreactors has shown promise as a mechanism to drive endothelial cell (EC) phenotype from an activated, pro-inflammatory wound state toward a quiescent functional state that inhibits responses that lead to occlusive failure. As part of an overall design strategy to engineer functional va ...[more]