Ontology highlight
ABSTRACT:
SUBMITTER: Heffern MC
PROVIDER: S-EPMC4638226 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Heffern Marie C MC Reichova Viktorie V Coomes Joseph L JL Harney Allison S AS Bajema Elizabeth A EA Meade Thomas J TJ
Inorganic chemistry 20150902 18
Cobalt(III) Schiff base complexes ([Co(acacen)(L)2](+), where L = NH3) inhibit histidine-containing proteins through dissociative exchange of the labile axial ligands (L). This work investigates axial ligand exchange dynamics of [Co(acacen)(L)2](+) complexes toward the development of protein inhibitors that are activated by external triggers such as light irradiation. We sought to investigate ligand exchange dynamics to design a Co(III) complex that is substitutionally inert under normal physiol ...[more]