Unknown

Dataset Information

0

Characterization and tissue distribution of conjugated metabolites of pyrene in the rat.


ABSTRACT: Pyrene (PY) is a polycyclic aromatic hydrocarbon (PAH) that is often used as a biomarker for human and wildlife exposure to PAHs. As the metabolites of PAHs, similar to their parent compounds, pose public health risks, it is necessary to study their characteristics and tissue-specific distribution. The present study was performed to experimentally characterize PY metabolites and analyze the tissue-specific distribution of the conjugated metabolites after oral administration of PY to rats. PY metabolites, such as pyrenediol-disulfate (PYdiol-diS), pyrenediol-sulfate (PYdiol-S), pyrene-1-sulfate (PYOS), pyrene-1-glucuronide (PYOG) and 1-hydroxypyrene (PYOH), were detected in rat urine. Although glucuronide conjugate was the predominant metabolite, the metabolite composition varied among tissues. Interestingly, the proportion of PYOH was high in the large intestine. Furthermore, PYOH was the only PY metabolite detected in feces.

SUBMITTER: Saengtienchai A 

PROVIDER: S-EPMC4638293 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Characterization and tissue distribution of conjugated metabolites of pyrene in the rat.

Saengtienchai Aksorn A   Ikenaka Yoshinori Y   Darwish Wageh Sobhy WS   Nakayama Shouta M M SM   Mizukawa Hazuki H   Ishizuka Mayumi M  

The Journal of veterinary medical science 20150601 10


Pyrene (PY) is a polycyclic aromatic hydrocarbon (PAH) that is often used as a biomarker for human and wildlife exposure to PAHs. As the metabolites of PAHs, similar to their parent compounds, pose public health risks, it is necessary to study their characteristics and tissue-specific distribution. The present study was performed to experimentally characterize PY metabolites and analyze the tissue-specific distribution of the conjugated metabolites after oral administration of PY to rats. PY met  ...[more]

Similar Datasets

| S-EPMC3316536 | biostudies-literature
| S-EPMC6427091 | biostudies-literature
| S-EPMC3485038 | biostudies-literature
| S-EPMC3815028 | biostudies-literature
| S-EPMC8146289 | biostudies-literature
| S-EPMC1586009 | biostudies-literature
| S-EPMC2662494 | biostudies-literature
| S-EPMC1172444 | biostudies-other
| S-EPMC1221321 | biostudies-other
| S-EPMC4496304 | biostudies-literature