Gut mucosal microbiome across stages of colorectal carcinogenesis.
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ABSTRACT:
SUBMITTER: Nakatsu G
PROVIDER: S-EPMC4640069 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Gut mucosal microbiome across stages of colorectal carcinogenesis.
Nakatsu Geicho G Li Xiangchun X Zhou Haokui H Sheng Jianqiu J Wong Sunny Hei SH Wu William Ka Kai WK Ng Siew Chien SC Tsoi Ho H Dong Yujuan Y Zhang Ning N He Yuqi Y Kang Qian Q Cao Lei L Wang Kunning K Zhang Jingwan J Liang Qiaoyi Q Yu Jun J Sung Joseph J Y JJ
Nature communications 20151030
Gut microbial dysbiosis contributes to the development of colorectal cancer (CRC). Here we catalogue the microbial communities in human gut mucosae at different stages of colorectal tumorigenesis. We analyse the gut mucosal microbiome of 47 paired samples of adenoma and adenoma-adjacent mucosae, 52 paired samples of carcinoma and carcinoma-adjacent mucosae and 61 healthy controls. Probabilistic partitioning of relative abundance profiles reveals that a metacommunity predominated by members of th ...[more]
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