Ontology highlight
ABSTRACT:
SUBMITTER: Yue M
PROVIDER: S-EPMC4640099 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Yue Min M Han Xiangan X De Masi Leon L Zhu Chunhong C Ma Xun X Zhang Junjie J Wu Renwei R Schmieder Robert R Kaushik Radhey S RS Fraser George P GP Zhao Shaohua S McDermott Patrick F PF Weill François-Xavier FX Mainil Jacques G JG Arze Cesar C Fricke W Florian WF Edwards Robert A RA Brisson Dustin D Zhang Nancy R NR Rankin Shelley C SC Schifferli Dieter M DM
Nature communications 20151030
Understanding the molecular parameters that regulate cross-species transmission and host adaptation of potential pathogens is crucial to control emerging infectious disease. Although microbial pathotype diversity is conventionally associated with gene gain or loss, the role of pathoadaptive nonsynonymous single-nucleotide polymorphisms (nsSNPs) has not been systematically evaluated. Here, our genome-wide analysis of core genes within Salmonella enterica serovar Typhimurium genomes reveals a high ...[more]