Ontology highlight
ABSTRACT:
SUBMITTER: Kharche SR
PROVIDER: S-EPMC4640177 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Kharche Sanjay R SR Stary Tomas T Colman Michael A MA Biktasheva Irina V IV Workman Antony J AJ Rankin Andrew C AC Holden Arun V AV Zhang Henggui H
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20140801 10
<h4>Aims</h4>Atrial anti-arrhythmic effects of β-adrenoceptor antagonists (β-blockers) may involve both a suppression of pro-arrhythmic effects of catecholamines, and an adaptational electrophysiological response to chronic β-blocker use; so-called 'pharmacological remodelling'. In human atrium, such remodelling decreases the transient outward (Ito) and inward rectifier (IK1) K(+) currents, and increases the cellular action potential duration (APD) and effective refractory period (ERP). However, ...[more]