Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC4640189 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Zhang Liman L Chen Shuobing S Ruan Jianbin J Wu Jiayi J Tong Alexander B AB Yin Qian Q Li Yang Y David Liron L Lu Alvin A Wang Wei Li WL Marks Carolyn C Ouyang Qi Q Zhang Xinzheng X Mao Youdong Y Wu Hao H
Science (New York, N.Y.) 20151008 6259
The NLR family apoptosis inhibitory proteins (NAIPs) bind conserved bacterial ligands, such as the bacterial rod protein PrgJ, and recruit NLR family CARD-containing protein 4 (NLRC4) as the inflammasome adapter to activate innate immunity. We found that the PrgJ-NAIP2-NLRC4 inflammasome is assembled into multisubunit disk-like structures through a unidirectional adenosine triphosphatase polymerization, primed with a single PrgJ-activated NAIP2 per disk. Cryo-electron microscopy (cryo-EM) recons ...[more]