S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.
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ABSTRACT:
SUBMITTER: Schudel A
PROVIDER: S-EPMC4640194 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
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S-Nitrosated Polypropylene Sulfide Nanoparticles for Thiol-Dependent Transnitrosation and Toxicity Against Adult Female Filarial Worms.
Schudel Alex A Kassis Timothy T Dixon J Brandon JB Thomas Susan N SN
Advanced healthcare materials 20150504 10
A synthetic polymer nanoparticle formulation utilizing the physiological nitrosothiol chemistry for nitric oxide delivery is shown. Toxicity of S-nitroso nanoparticles against adult female Brugia malayi worms, which are responsible for lymphatic filariasis, is dependent on nitric oxide release through transnitrosation as S-nitrosocysteine, a potent endogenous nitric oxide donor. ...[more]
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