Ontology highlight
ABSTRACT:
SUBMITTER: Hue CD
PROVIDER: S-EPMC4640274 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Hue Christopher D CD Cho Frances S FS Cao Siqi S Dale Bass Cameron R CR Meaney David F DF Morrison Barclay B
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20150311 7
Owing to the frequent incidence of blast-induced traumatic brain injury (bTBI) in recent military conflicts, there is an urgent need to develop effective therapies for bTBI-related pathologies. Blood-brain barrier (BBB) breakdown has been reported to occur after primary blast exposure, making restoration of BBB function and integrity a promising therapeutic target. We tested the hypothesis that treatment with dexamethasone (DEX) after primary blast injury potentiates recovery of an in vitro BBB ...[more]