Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC4640771 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Li Qufei Q Shen Rong R Treger Jeremy S JS Wanderling Sherry S SS Milewski Wieslawa W Siwowska Klaudia K Bezanilla Francisco F Perozo Eduardo E
Proceedings of the National Academy of Sciences of the United States of America 20151006 44
The voltage-gated proton channel Hv1 plays a critical role in the fast proton translocation that underlies a wide range of physiological functions, including the phagocytic respiratory burst, sperm motility, apoptosis, and metastatic cancer. Both voltage activation and proton conduction are carried out by a voltage-sensing domain (VSD) with strong similarity to canonical VSDs in voltage-dependent cation channels and enzymes. We set out to determine the structural properties of membrane-reconstit ...[more]