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A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.


ABSTRACT: By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections.

SUBMITTER: Shirani H 

PROVIDER: S-EPMC4641461 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.

Shirani Hamid H   Linares Mathieu M   Sigurdson Christina J CJ   Lindgren Mikael M   Norman Patrick P   Nilsson K Peter R KP  

Chemistry (Weinheim an der Bergstrasse, Germany) 20150921 43


By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections. ...[more]

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