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A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.

ABSTRACT: By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections.

SUBMITTER: Shirani H

PROVIDER: S-EPMC4641461 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.

Shirani Hamid H Linares Mathieu M Sigurdson Christina J CJ Lindgren Mikael M Norman Patrick P Nilsson K Peter R KP

Chemistry (Weinheim an der Bergstrasse, Germany) 20150921 43

By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections. ...[more]

PMID: 26388448

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