Ontology highlight
ABSTRACT:
SUBMITTER: Shen SM
PROVIDER: S-EPMC4641507 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Shen Shao-Ming SM Guo Meng M Xiong Zhong Z Yu Yun Y Zhao Xu-Yun XY Zhang Fei-Fei FF Chen Guo-Qiang GQ
EMBO reports 20150928 11
Apoptosis-inducing factor (AIF) exerts dual roles on cell death and survival, but its substrates as a putative oxidoreductase and roles in tumorigenesis remain elusive. Here, we report that AIF physically interacts with and inhibits the oxidation of phosphatase and tensin homolog on chromosome ten (PTEN), a tumor suppressor susceptible for oxidation-mediated inactivation. More intriguingly, we also identify PTEN as a mitochondrial protein and the ectopic expression of mitochondrial targeting seq ...[more]