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Scaffold-free cartilage subjected to frictional shear stress demonstrates damage by cracking and surface peeling.

ABSTRACT: Scaffold-free engineered cartilage is being explored as a treatment for osteoarthritis. In this study, frictional shear stress was applied to determine the friction and damage behaviour of scaffold-free engineered cartilage, and tissue composition was investigated as it related to damage. Scaffold-free engineered cartilage frictional shear stress was found to exhibit a time-varying response similar to that of native cartilage. However, damage occurred that was not seen in native cartilage, manifesting primarily as tearing through the central plane of the constructs. In engineered cartilage, cells occupied a significantly larger portion of the tissue in the central region where damage was most prominent (18?±?3% of tissue was comprised of cells in the central region vs 5?±?1% in the peripheral region; p?

SUBMITTER: Whitney GA

PROVIDER: S-EPMC4641823 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

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Scaffold-free cartilage subjected to frictional shear stress demonstrates damage by cracking and surface peeling.

Whitney G Adam GA Jayaraman Karthik K Dennis James E JE Mansour Joseph M JM

Journal of tissue engineering and regenerative medicine 20140626 2

Scaffold-free engineered cartilage is being explored as a treatment for osteoarthritis. In this study, frictional shear stress was applied to determine the friction and damage behaviour of scaffold-free engineered cartilage, and tissue composition was investigated as it related to damage. Scaffold-free engineered cartilage frictional shear stress was found to exhibit a time-varying response similar to that of native cartilage. However, damage occurred that was not seen in native cartilage, manif ...[more]

PMID: 24965503

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