Ontology highlight
ABSTRACT:
SUBMITTER: Shao B
PROVIDER: S-EPMC4642332 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Shao Bin B Wei Xiawei X Luo Min M Yu Jiayun J Tong Aiping A Ma Xuelei X Ye Tinghong T Deng Hongxin H Sang Yaxiong Y Liang Xiao X Ma Yu Y Wu Qinjie Q Du Wei W Du Jing J Gao Xiang X Wen Yi Y Fu Ping P Shi Huashan H Luo Shuntao S Wei Yuquan Y
Scientific reports 20151112
Myeloid-derived suppressor cells (MDSCs) are known to play important roles in the development of immunosuppressive tumor microenvironment. A20 is a zinc-finger protein which could negatively regulate apoptosis in several cell types. However, the role of A20 in tumor microenvironment remains largely unknown. In this study, we found that A20 was over-expressed in MDSCs. The treatment of tumor-bearing mice with small interfering RNA targeting A20 (si-A20) inhibited the growth of tumors. The infiltr ...[more]