Pathway-Based Genome-wide Association Studies Reveal That the Rac1 Pathway Is Associated with Plasma Adiponectin Levels.
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ABSTRACT:
SUBMITTER: Li WD
PROVIDER: S-EPMC4642532 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
Pathway-Based Genome-wide Association Studies Reveal That the Rac1 Pathway Is Associated with Plasma Adiponectin Levels.
Li Wei-Dong WD Jiao Hongxiao H Wang Kai K Yang Fuhua F Grant Struan F A SF Hakonarson Hakon H Ahima Rexford R Arlen Price R R
Scientific reports 20150824
Pathway-based analysis as an alternative and effective approach to identify disease-related genes or loci has been verified. To decipher the genetic background of plasma adiponectin levels, we performed genome wide pathway-based association studies in extremely obese individuals and normal-weight controls. The modified Gene Set Enrichment Algorithm (GSEA) was used to perform the pathway-based analyses (the GenGen Program) in 746 European American females, which were collected from our previous G ...[more]
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