Ontology highlight
ABSTRACT:
SUBMITTER: Deng L
PROVIDER: S-EPMC4642534 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Deng Long L Hong Tao T Lin Jinyi J Ding Suling S Huang Zheyong Z Chen Jinmiao J Jia Jianguo J Zou Yunzeng Y Wang Timothy C TC Yang Xiangdong X Ge Junbo J
Scientific reports 20150817
Histamine is a biogenic amine that is widely distributed and has multiple functions, but the role it plays in acute myocardial infarction (AMI) remains unclear. In this study, we investigated the origin and contribution of endogenous histamine to AMI. Histidine decarboxylase (HDC) is the unique enzyme responsible for histamine generation. Using HDC-EGFP bacterial artificial chromosome (BAC) transgenic mice in which EGFP expression is controlled by the HDC promoter, we identified HDC expression p ...[more]